STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane.

Elisabetta Rubini Fabio Altieri Silvia Chichiarelli Flavia GiamoganteStefania CarissimiGiuliano Paglia Alberto BoffiMargherita Eufemi

Published in: International journal of molecular sciences (2018)

The preliminary results allow us to hypothesize the involvement of STAT3, through both its canonical and non-canonical pathways, in response to β-HCH. Moreover, we ascertained the role of STAT3 as a master regulator of energy metabolism via the altered expression and localization of HIF-1α and PKM2, respectively, resulting in a Warburg-like effect.

Keyphrases

cell proliferation
signaling pathway
poor prognosis
binding protein
transcription factor
endothelial cells
epithelial mesenchymal transition
pi k akt
protein protein
small molecule
long non coding rna
bioinformatics analysis