Inhibition of the glucocorticoid receptor attenuates proteinuric kidney diseases in multiple species.
Eleni StamellouShipra AgrawalFlorian SiegeristMarc BuseChristoph KuppeTim LangeEva Miriam BuhlJessica AlamThiago StriederPeter BoorTammo OstendorfHermann-Josef GröneJürgen FloegeWilliam E SmoyerNicole EndlichMarcus J MoellerPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023)
Thus, across multiple species and proteinuria models, both genetic and pharmacological GR inhibition was at least as effective as pronounced GR activation. While, the mechanism remains perplexing, GR inhibition may be a novel and targeted therapeutic approach to treat glomerular proteinuria potentially bypassing adverse actions of steroids.