The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial.
Kay WangMalcolm Gracie SempleMichael MooreAlastair D HaySharon TonnerUshma GalalJenna GrabeyTricia CarverRafael PereraLy-Mee YuJill MollisonPaul LittleAndrew FarmerChristopher C ButlerAnthony HarndenPublished in: The European respiratory journal (2021)
Our trial did not find evidence that treatment with co-amoxiclav reduces risk of reconsultation due to clinical deterioration in "at risk" children who present early with ILI during influenza season. Our findings therefore do not support early co-amoxiclav use in children with seasonal ILI.