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Genomic Analysis of Vascular Invasion in HCC Reveals Molecular Drivers and Predictive Biomarkers.

Maya S KrishnanAnand Rajan KdJangho ParkVinodhini ArjunanFernando Jose Garcia MarquesAbel BermudezOlivia A GirvanNam S HoangJun YinMindie H NguyenNishita KotharySharon PitteriDean W FelsherRenumathy Dhanasekaran
Published in: Hepatology (Baltimore, Md.) (2021)
Our study evaluates the molecular landscape of tumors with VI, identifying distinct transcriptional, epigenetic, and proteomic changes driven by the MYC oncogene. We show that MYC up-regulates fibronectin expression, which promotes HCC invasiveness. In addition, we identify fibronectin to be a promising noninvasive proteomic biomarker of VI in HCC.
Keyphrases
  • transcription factor
  • gene expression
  • poor prognosis
  • dna methylation
  • type iii
  • label free
  • single molecule
  • binding protein
  • long non coding rna
  • heat shock