An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.
Mark W LogueMark W MillerErika J WolfBertrand Russ HuberFilomene G MorrisonZhenwei ZhouYuanchao ZhengAlicia K SmithNikolaos P DaskalakisAndrew RatanatharathornMonica UddinCaroline M NievergeltAllison E Ashley-KochDewleen G BakerJean C BeckhamMelanie E GarrettMarco P BoksElbert GeuzeGerald A GrantMichael A HauserRonald C KesslerNathan A KimbrelAdam X MaihoferChristine E MarxXue-Jun QinVictoria B RisbroughBart P F RuttenMurray B SteinRobert J UrsanoEric VermettenChristiaan H VinkersErin B WareAnnjanette StoneSteven A SchichmanRegina E McGlincheyWilliam P MilbergJasmeet P HayesMieke Verfaellienull nullPublished in: Clinical epigenetics (2020)
The cross replication observed in independent cohorts is evidence that DNA methylation in peripheral tissue can yield consistent and replicable PTSD associations, and our results also suggest that that some PTSD associations observed in peripheral tissue may mirror associations in the brain.