A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology.
Thomas R MüllerCorinna SchulerMonika HammelAmelie KöhlerSabrina JutzJudith LeitnerKilian SchoberDirk H BuschPeter SteinbergerPublished in: Clinical & translational immunology (2020)
Overall, our data show that the TPRKO cell lines can serve as a surrogate of primary human T cells for standardised and high-throughput investigation of TCR biology.