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A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology.

Thomas R MüllerCorinna SchulerMonika HammelAmelie KöhlerSabrina JutzJudith LeitnerKilian SchoberDirk H BuschPeter Steinberger
Published in: Clinical & translational immunology (2020)
Overall, our data show that the TPRKO cell lines can serve as a surrogate of primary human T cells for standardised and high-throughput investigation of TCR biology.
Keyphrases
  • high throughput
  • regulatory t cells
  • endothelial cells
  • single cell
  • electronic health record
  • crispr cas
  • induced pluripotent stem cells
  • big data
  • dendritic cells
  • immune response