A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology.

Thomas R MüllerCorinna SchulerMonika HammelAmelie KöhlerSabrina JutzJudith Leitner Kilian Schober Dirk H Busch Peter Steinberger

Published in: Clinical & translational immunology (2020)

Overall, our data show that the TPRKO cell lines can serve as a surrogate of primary human T cells for standardised and high-throughput investigation of TCR biology.

Keyphrases

high throughput
regulatory t cells
endothelial cells
single cell
electronic health record
crispr cas
induced pluripotent stem cells
big data
dendritic cells
immune response