Both Disease Activity and HLA-B27 Status Are Associated With Gut Microbiome Dysbiosis in Spondyloarthritis Patients.

Magali BerlandVictoria MeslierSamar Berreira IbraimEmmanuelle Le ChatelierNicolas PonsNicolas MaziersFlorence ThirionFranck GauthierFlorian Plaza OñateJean-Pierre FuretAriane LeboimeRoula Said-NahalFlorence LevenezNathalie GalleronBenoît QuinquisPhilippe LangellaStanislav Dusko EhrlichMaxime Breban

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

These findings reveal that genetic background and level of disease activity are likely to influence the composition of the gut microbiota of patients with SpA. It may be appropriate for further research on chronic arthritis to focus on these key parameters.

Keyphrases

disease activity
rheumatoid arthritis
systemic lupus erythematosus
ankylosing spondylitis
rheumatoid arthritis patients
juvenile idiopathic arthritis
end stage renal disease
ejection fraction
chronic kidney disease
genome wide
newly diagnosed
peritoneal dialysis
copy number
patient reported outcomes
single cell