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Electroreductive Radical Addition-Polar Cyclization Cascade to Access Cycloalkanes.

Yi WangJiachen DengAndrew J ResslerSong Lin
Published in: Organic letters (2023)
Compared with flat aromatic scaffolds, three-dimensional aliphatic ring systems feature high structural complexity and topological diversity and, thus, have received increasing attention in drug discovery. Herein, we describe a mild and general electrochemical method for the modular synthesis of structurally distinct cyclic compounds, including monocyclic alkanes, benzo-fused ring systems, and spirocycles, from readily available alkenes and alkyl halides via a radical-polar crossover mechanism.
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