DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules.
Guanshi ZhangJialing ZhangRachel J DeHoogSubramaniam PennathurChristopher R AndertonManjeri A VenkatachalamTheodore AlexandrovLivia S EberlinKumar SharmaPublished in: Metabolomics : Official journal of the Metabolomic Society (2020)
Results from the current study support potential key roles of pseudouridine and cardiolipins for maintaining normal RNA structure and normal mitochondrial function, respectively, in cortical proximal tubules with DKD. DESI-MSI technology coupled with METASPACE could serve as powerful new tools to provide insight on fundamental pathways in DKD.