Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse.

Chinmayee SethyKunal GoutamDeepika NayakRajalaxmi PradhanSefinew MollaSubhajit ChatterjeeNiranjan RoutMichael D WyattSatya NarayanChanakya Nath Kundu

Published in: Journal of cancer research and clinical oncology (2019)

Our study demonstrated a significant correlation between Nectin-4 expression and tumor grade as well as stages (p < 0.001), suggesting its association with tumor progression. Nectin-4 was overexpressed at all stages of metastasis and angiogenesis, thus appearing to play a major role in tumor relapse through the PI3K-Akt-NFκβ pathway.

Keyphrases

poor prognosis
endothelial cells
vascular endothelial growth factor
signaling pathway
oxidative stress
long non coding rna
genome wide
free survival
copy number
nuclear factor
toll like receptor
transcription factor