Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilization with fresh respectively frozen-thawed embryo transfer: Nationwide cohort study.
Nina OlaussonAndrea DiscacciatiAnastasia I NymanFrida LundbergOuti HovattaEli WesterlundHåkan N WallénFariborz MobarrezMatteo BottaiAnders EkbomPeter HenrikssonPublished in: Journal of thrombosis and haemostasis : JTH (2020)
Women giving birth after fresh embryo transfer IVF had a more than eightfold increased incidence of venous thromboembolism (hazard ratio [HR] 8.96, 95% CI 6.33 to 12.67) and pulmonary embolism during the first trimester, (HR 8.69, 95% CI 3.83 to 19.71) compared to women giving birth after natural conception. The incidence of VTE in women giving birth after frozen-thawed embryo transfer was not increased during the first trimester. To conclude, fresh embryo transfer IVF was associated with a significantly increased incidence of VTE and PE during the first trimester. These results suggest that frozen-thawed embryo transfer could be a preferred method of IVF with a minimised maternal risk.
Keyphrases
- pregnancy outcomes
- venous thromboembolism
- pulmonary embolism
- pregnant women
- risk factors
- direct oral anticoagulants
- inferior vena cava
- pulmonary hypertension
- type diabetes
- gestational age
- body mass index
- polycystic ovary syndrome
- cross sectional
- physical activity
- preterm birth
- insulin resistance
- adipose tissue
- atrial fibrillation
- birth weight