Fabrication of Nanocrystals for Enhanced Distribution of a Fatty Acid Synthase Inhibitor (Orlistat) as a Promising Method to Relieve Solid Ehrlich Carcinoma-Induced Hepatic Damage in Mice.

Jawaher Abdullah AlamoudiThanaa A El-MasryMohamed NasrIsmail T IbrahimHanaa A IbrahimHebatallah M Saad Maysa M F El-Nagar Samar Zuhair Alshawwa Amal AlrashidiEnas I El Zahaby

Published in: Pharmaceuticals (Basel, Switzerland) (2024)

The developed ORL-NC could be considered a promising formulation approach to enhance the oral absorption tissue distribution of ORL and suppress the liver damage caused by SEC.

Keyphrases

fatty acid
oxidative stress
diabetic rats
high glucose
drug delivery
high fat diet induced
room temperature
drug induced
low cost
metabolic syndrome
insulin resistance
ionic liquid