RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway.

Omprakash ShriwasRakesh AryaSibasish MohantyPallavi MohapatraSugandh KumarRachna RathSandeep Rai KaushikFalak PahwaKrushna Chandra MurmuSaroj Kumar Das MajumdarDillip Kumar MudulyAnshuman DixitPunit PrasadRanjan K NandaRupesh Dash

Published in: British journal of cancer (2021)

Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC.

Keyphrases

poor prognosis
electronic health record
machine learning
deep learning