The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats.

Jing MaoYa LiQingqing BianYinshuang XuanJingmei LiZhikun WangSuxiang FengXuefang LiuYange TianSuyun Li

Published in: International journal of chronic obstructive pulmonary disease (2022)

Overall, BJF administration improved mucosal immune function by remodeling the gut microbiota and suppressing the SCFAs/GPR43/NLRP3 pathway in COPD rats. This study provides evidence for the mechanisms underlying BJF-induced improvements in COPD and supports clinical application of BJF.

Keyphrases

chronic obstructive pulmonary disease
lung function
fatty acid
ulcerative colitis
nlrp inflammasome
human milk
drug induced
preterm infants
low birth weight