Human Leukocyte Antigen Mismatching and Survival in Contemporary Hematopoietic Cell Transplantation for Hematologic Malignancies.
Esteban Arrieta-BolañosEdouard F BonnevillePietro CrivelloMarie RobinTobias Gedde-DahlUrpu SalmenniemiNicolaus KrögerIbrahim Yakoub AghaCharles CrawleyGoda ChoiAnnoek E C BroersEdouard ForcadeMartin CarreXavier PoiréAnne HuynhStig LenhoffFabio CiceriEleni TholouliThomas SchroederErick DeconinckKristina CarlsonLiesbeth C de WreedeJorinde D HoogenboomFlorent MalardAnnalisa RuggeriKatharina Fleischhauernull nullPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Class I but not class II HLA mismatches, especially at the antigen and PBM level, are associated with inferior survival in contemporary unrelated HCT. These effects are not significantly different between non-PTCy compared with PTCy transplants. Optimized HLA matching should still be considered in modern HCT.