Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren's Syndrome.
Giada De BenedittisCinzia CiccacciAndrea LatiniLucia NovelliGiuseppe NovelliPaola BorgianiPublished in: Genes (2021)
Sjögren's Syndrome (SS) is a chronic autoimmune inflammatory disease. It is considered a multifactorial pathology, in which underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to development. The epigenetic regulations represent a link between genetic predisposition and environmental factors. Recent studies suggested a regulatory role for non-coding RNAs in critical biological and disease processes. Among non-coding RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play a critical role in the post-transcriptional mRNA expression, forming a complex network of gene expression regulation. This review aims to give an overview of the latest studies that have investigated the role of miRNAs and lncRNAs in the SS. We included papers that investigated the expression of non-coding RNAs on different tissues, in particular on peripheral blood mononuclear cells and salivary glands. However, regarding the involvement of non-coding RNAs genetic variability in SS susceptibility very few data are available. Further research could help to elucidate underlying pathogenic processes of SS and provide new opportunities for the development of targeted therapies.
Keyphrases
- long non coding rna
- gene expression
- poor prognosis
- dna methylation
- genome wide
- copy number
- transcription factor
- disease activity
- multiple sclerosis
- case report
- oxidative stress
- network analysis
- case control
- systemic lupus erythematosus
- electronic health record
- machine learning
- rheumatoid arthritis
- heat shock
- binding protein
- big data
- artificial intelligence
- data analysis