Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis.

Shivan SivakumarInes de SantiagoLeon ChlonFlorian Markowetz

Published in: PLoS medicine (2017)

Our results characterize the regulatory mechanisms underlying the transcriptional response to oncogenic KRAS and provide a framework to develop strategies for specific subtypes of this disease using current therapeutics and by identifying targets for new groups.

Keyphrases

transcription factor
wild type
gene expression
small molecule
network analysis
heat shock
data analysis
heat shock protein