A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest.
Simon MølstrømTroels Halfeld NielsenCarl-Henrik NordstrømAxel ForsseSøren MøllerSøren VenøDmitry MamaevTomas TencerÁsta TheódórsdóttirThomas KrøigårdJacob MøllerChristian HassagerJesper KjærgaardHenrik SchmidtPalle ToftPublished in: Critical care (London, England) (2023)
Among comatose patients resuscitated from OHCA, targeting a higher MAP 180 min after ROSC did not significantly improve cerebral energy metabolism within 96 h of post-resuscitation care. Patients with a poor clinical outcome exhibited significantly worse biochemical patterns, probably illustrating that insufficient tissue oxygenation and recirculation during the initial hours after ROSC were essential factors determining neurological outcome.
Keyphrases
- cardiac arrest
- blood pressure
- end stage renal disease
- clinical trial
- healthcare
- newly diagnosed
- chronic kidney disease
- cardiopulmonary resuscitation
- study protocol
- double blind
- ejection fraction
- palliative care
- phase iii
- cerebral ischemia
- phase ii
- prognostic factors
- subarachnoid hemorrhage
- white matter
- heart rate
- quality improvement
- randomized controlled trial
- cancer therapy
- multiple sclerosis
- pain management
- placebo controlled
- blood brain barrier
- blood glucose
- patient reported outcomes
- chronic pain
- patient reported
- septic shock