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Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression.

Elisa AquilantiSilvia GoldoniAndrew BakerKristyna KotynkovaSawyer AndersenVincent BozinovGalen F GaoAndrew D CherniackMartin LangeRalf LescheCharlotte KopitzPhilip LienauTimothy A LewisMarine GarridoStefan GradlHenrik SeidelYuen-Yi TsengKeith L LigonPatrick Y WenMatthew MeyersonHeidi Greulich
Published in: Neuro-oncology advances (2024)
Velcrins have antitumor activity in preclinical models of glioblastoma, warranting further investigation as potential therapeutic agents.
Keyphrases
  • poor prognosis
  • oxidative stress
  • endoplasmic reticulum stress
  • cell cycle arrest
  • cell death
  • long non coding rna
  • single molecule
  • stem cells
  • cell proliferation
  • signaling pathway