Dose-linearity of the pharmacokinetics of an intravenous [14 C]midazolam microdose in children.

Bianca D van GroenWouter H VaesB Kevin ParkElke H J KrekelsEsther van DuijnLenne-Triin KõrgveeWioleta MaruszakGrzegorz GrynkiewiczR Colin GarnerCatherijne A J KnibbeDick TibboelSaskia N de WildtMark A Turner

Published in: British journal of clinical pharmacology (2019)

Our data support the dose linearity of the PK of an IV [14 C]midazolam microdose in children. Hence, a [14 C]midazolam microdosing approach may be used as an alternative to a therapeutic dose of midazolam to study developmental changes in hepatic CYP3A activity in young children.

Keyphrases

young adults
high dose
big data
machine learning
artificial intelligence