Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions.
Sophie RousseauxEmie SeyveFlorent ChuffartEkaterina Bourova-FlinMeriem BenmeradMarie-Aline CharlesAnne ForhanBarbara HeudeValérie SirouxRemy SlamaJorg TostDaniel VaimanSaadi KhochbinJohanna Lepeulenull nullPublished in: BMC medicine (2020)
Our results pointing towards genomic regions containing the imprinted genes as well as enhancers as preferential targets suggest mechanisms by which tobacco could directly impact the fetus and future child. The persistence of significant DNA methylation changes in the placenta of former smokers supports the hypothesis of an "epigenetic memory" of exposure to cigarette smoking before pregnancy. This observation not only is conceptually revolutionary, but these results also bring crucial information in terms of public health concerning potential long-term detrimental effects of smoking in women.
Keyphrases
- dna methylation
- genome wide
- pregnancy outcomes
- copy number
- public health
- smoking cessation
- gene expression
- pregnant women
- genome wide identification
- mental health
- transcription factor
- polycystic ovary syndrome
- working memory
- binding protein
- solid phase extraction
- current status
- birth weight
- type diabetes
- global health
- preterm birth
- body mass index
- mass spectrometry
- bioinformatics analysis
- skeletal muscle
- metabolic syndrome
- breast cancer risk
- climate change
- high resolution