Patients born with complex congenital heart defects, not amenable for surgical repair establishing normal bi-ventricular circulation are palliated with the Fontan Circulation (FC). Here, we report new iPSC line from a patient with tricuspid and pulmonary atresia. The patient underwent series of surgeries leading to completion of Fontan circulation at the age of 13yr., and this line was generated when she was 38yr. old. The exact genetic cause of this patient's congenital heart defect is unknown, and this line will be used for studying molecular and cellular mechanisms responsible for cardiac dysfunction, along with screening for future potential therapeutic avenues.
Keyphrases
- case report
- end stage renal disease
- left ventricular
- endothelial cells
- chronic kidney disease
- induced pluripotent stem cells
- oxidative stress
- gene expression
- mitral valve
- ejection fraction
- preterm infants
- minimally invasive
- genome wide
- dna methylation
- prognostic factors
- aortic valve
- peritoneal dialysis
- transcatheter aortic valve replacement
- copy number
- pluripotent stem cells