Prognostic role of the systemic immune-inflammation index in upper tract urothelial carcinoma treated with radical nephroureterectomy: results from a large multicenter international collaboration.

Keiichiro MoriIrene ReschNoriyoshi MiuraEkaterina LaukhtinaVictor M SchuettfortBenjamin PradereSatoshi KatayamaDavid D'AndreaMehdi Kardoust PariziMohammad AbufarajWataru FukuokayaClaudia Collà RuvoloStefano LuzzagoSophie KnipperCarlotta PalumboPierre I KarakiewiczAlberto BrigantiDmitry V EnikeevMorgan RouprêtVitaly MargulisShin EgawaShahrokh F Shariat

Published in: Cancer immunology, immunotherapy : CII (2021)

Preoperative altered SII is significantly associated with higher pathologic stages and worse survival outcomes in patients treated with RNU for UTUC. However, the SII appears to have relatively limited incremental additive value in clinical use. Further study of SII in prognosticating UTUC is warranted before routine use in clinical algorithms.

Keyphrases

machine learning
oxidative stress
deep learning
squamous cell carcinoma
cross sectional
locally advanced
newly diagnosed