PBRM1 loss is a late event during the development of cholangiocarcinoma.
Claudio LuchiniScott A RobertsonSeung-Mo HongMatthäus FelsensteinRobert A AndersAntonio PeaAlessia NottegarNicola VeroneseJin HeMatthew J WeissPaola CapelliAldo ScarpaPedram ArganiPayal KapurLaura D WoodPublished in: Histopathology (2017)
These findings indicate that PBRM1 mutation (and resultant loss of expression) is a late event during biliary carcinogenesis. In addition, we confirm a lack of prognostic significance of PBRM1 status in invasive intrahepatic cholangiocarcinoma. This study provides important insights into the basic mechanisms of chromatin remodelling genes in carcinogenesis.