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PBRM1 loss is a late event during the development of cholangiocarcinoma.

Claudio LuchiniScott A RobertsonSeung-Mo HongMatthäus FelsensteinRobert A AndersAntonio PeaAlessia NottegarNicola VeroneseJin HeMatthew J WeissPaola CapelliAldo ScarpaPedram ArganiPayal KapurLaura D Wood
Published in: Histopathology (2017)
These findings indicate that PBRM1 mutation (and resultant loss of expression) is a late event during biliary carcinogenesis. In addition, we confirm a lack of prognostic significance of PBRM1 status in invasive intrahepatic cholangiocarcinoma. This study provides important insights into the basic mechanisms of chromatin remodelling genes in carcinogenesis.
Keyphrases
  • genome wide
  • poor prognosis
  • gene expression
  • dna damage
  • transcription factor
  • binding protein