Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy.
Pavan K BhatrajuLeila R ZelnickJerald HertingRonit KatzCarmen MikacenicSusanna Harju-BakerEric D MorrellCassianne Robinson-CohenCarolyn S CalfeeJason D ChristieKathleen D LiuMichael A MatthayWilliam O HahnVictoria DmyterkoNatalie S J SlivinskiJim A RussellKeith R WalleyDavid C ChristianiW Conrad LilesJonathan HimmelfarbMark M WurfelPublished in: American journal of respiratory and critical care medicine (2020)
This analysis identified two molecularly distinct AKI subphenotypes with different clinical outcomes and responses to vasopressin therapy. Identification of AKI subphenotypes could improve risk prognostication and may be useful for predictive enrichment in clinical trials.