ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells.

Cecilia BergonziniAlessandro GregoriTessa M S HagensVera E van der NoordBob van de WaterAnnelien J M ZweemerBircan CobanMjriam CapulaGiulia MantiniAsia BottoFrancesco FinamoreIngrid GarajovaLiam A McDonnellThomas SchmidtElisa GiovannettiErik H J Danen

Published in: Journal of experimental & clinical cancer research : CR (2024)

Upregulation of ABCB1 through locus amplification represents a novel, conserved mechanism of PDAC paclitaxel resistance. Kinase inhibitors identified in this study can be further (pre) clinically explored as therapeutic strategies to overcome paclitaxel resistance in PDAC.

Keyphrases

cell proliferation
transcription factor
nucleic acid
poor prognosis
genome wide association study