Cortical and Subthalamic Nucleus Spectral Changes During Limb Movements in Parkinson's Disease Patients with and Without Dystonia.
Joseph W OlsonArie NakhmaniZachary T IrwinLloyd J EdwardsChristopher L GonzalezMelissa H WadeSarah D BlackMohammad Z AwadDaniel J KuhmanChristopher P HurtBart L GuthrieHarrison C WalkerPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
Spectral power in motor cortex and STN field potentials differs markedly during repetitive limb movements, with cortical beta desynchronization and subcortical low-frequency synchronization, especially in patients with PD with dystonia. Greater knowledge on field potential dynamics in human motor circuits can inform dystonia pathophysiology in PD and guide novel approaches to therapy. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- deep brain stimulation
- parkinson disease
- optical coherence tomography
- early onset
- endothelial cells
- healthcare
- high frequency
- dual energy
- induced pluripotent stem cells
- white matter
- randomized controlled trial
- magnetic resonance imaging
- risk assessment
- human health
- multiple sclerosis
- mesenchymal stem cells
- replacement therapy