Characterization of Angiogenic, Matrix Remodeling, and Antimicrobial Factors in Preterm and Full-Term Human Umbilical Cords.
Kaiva Zile ZarinaMara PilmanePublished in: Journal of developmental biology (2024)
Extracellular matrix remodeling in preterm and term umbilical cords is strongly regulated, and tissue factors MMP2 and TIMP2 take part in this process. The expression of VEGF is not affected by the umbilical cord's age; however, individual patient factors can affect the production of VEGF. Numerous CD34-positive cells in the endothelium of the umbilical arteries suggest a significant role of progenitor cells in very preterm and moderate preterm birth umbilical cords. Antimicrobial activity provided by HBD2 is essential and constant in preterm and full-term umbilical cords.
Keyphrases
- gestational age
- preterm birth
- low birth weight
- preterm infants
- extracellular matrix
- umbilical cord
- mesenchymal stem cells
- endothelial cells
- vascular endothelial growth factor
- induced apoptosis
- poor prognosis
- staphylococcus aureus
- nitric oxide
- high intensity
- case report
- transcription factor
- binding protein
- long non coding rna
- cell proliferation
- cell death
- endoplasmic reticulum stress