Absorption, metabolism and excretion of opicapone in human healthy volunteers.
Ana I LoureiroFrancisco RochaAna T SantosNand SinghMaria João BonifácioRui PintoLaszlo E KissPatricio Soares-Da-SilvaPublished in: British journal of clinical pharmacology (2022)
C]-opicapone was fully excreted through multiple metabolic pathways. The main route of excretion was in faeces, where opicapone may be further metabolized via reductive metabolism involving the 1,2,4-oxadiazole ring-opening and subsequent hydrolysis.