Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker.
Felicitas SchmidMatthias DahlmannHanna RöhrichDennis KobeltJens HoffmannSusen BurockWolfgang WaltherUlrike SteinPublished in: British journal of cancer (2022)
We identified S100P as a transcriptional target gene of MACC1. Expression of S100P increases the metastatic potential of CRC cells in vitro and in vivo, and serves as a prognostic biomarker for metastasis-free survival of CRC patients, emphasising novel therapeutic interventions targeting S100P.
Keyphrases
- binding protein
- free survival
- end stage renal disease
- copy number
- ejection fraction
- newly diagnosed
- induced apoptosis
- small cell lung cancer
- genome wide
- squamous cell carcinoma
- gene expression
- poor prognosis
- transcription factor
- physical activity
- genome wide identification
- cancer therapy
- risk assessment
- dna methylation
- cell proliferation
- signaling pathway
- genome wide analysis
- patient reported outcomes
- human health
- drug delivery
- heat stress