Functional validation of nicotinic acetylcholine receptor (nAChR) α6 as a target of spinosyns in Spodoptera exigua utilizing the CRISPR/Cas9 system.
Yayun ZuoYuxin XueWenjie LuHuanhuan MaMao Hua ChenYi-Dong WuYihua YangZhao-Nong HuPublished in: Pest management science (2020)
The results clearly demonstrated the functional role of Seα6 in resistance to spinosyn insecticides and provide an example of using genome editing to verify a target premature truncation associated with resistance.
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