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Low-dose metformin suppresses hepatocellular carcinoma metastasis via the AMPK/JNK/IL-8 pathway.

Chengwen ZhaoLu ZhengYuting MaYue ZhangChanjuan YueFeng GuGuoping NiuYongqiang Chen
Published in: International journal of immunopathology and pharmacology (2024)
The results indicate that low-dose metformin can inhibit HCC metastasis by suppressing IL-8 expression. Targeting the AMPK/JNK/IL-8 axis may be a promising treatment strategy for patients with HCC metastasis.
Keyphrases
  • low dose
  • signaling pathway
  • high dose
  • cell death
  • skeletal muscle
  • poor prognosis
  • induced apoptosis
  • cancer therapy
  • oxidative stress
  • binding protein
  • drug delivery
  • endoplasmic reticulum stress