Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease.
Tarek A AhmedKhalid Mohamed El-SayFathy I Abd-AllahAbdelsattar Mansour Omar EbeidMoustafa E El-ArabyYosra A MuhammadPiyusha P PagareYan ZhangKhadijah A MohmmadOsheiza AbdulmalikMartin K SafoPublished in: Pharmaceutics (2021)
Oral and IV formulations of PP10 were successfully developed using HP-β-CD binary system and TPGS aqueous micelles, respectively, resulting in significantly improved solubility and bioavailability.