Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology.
Ewa MatuszczakMarzena TylickaMarta Diana KomarowskaWojciech DebekAdam HermanowiczPublished in: Cell biochemistry and function (2020)
Ubiquitin C-terminal hydrolase 1 (UCHL1) is an enzyme unique for its multiple activity - both ligase and hydrolase. UCHL1 was first identified as an abundant protein found in the brain and testes, however its expression is not limited to the neuronal compartment. UCHL1 is also highly expressed in carcinomas of various tissue origins, including those from brain, lung, breast, kidney, colon, prostate, pancreas and mesenchymal tissues. Loss-of-function studies and an inhibitor for UCHL1 confirmed the importance of UCHL1 for cancer therapy. So far biological significance of UCHL1 was described in the following processes: spermatogenesis, oncogenesis, angiogenesis, cell proliferation and differentiation in skeletal muscle, inflammation, tissue injury, neuronal injury and neurodegeneration.
Keyphrases
- skeletal muscle
- cell proliferation
- cancer therapy
- cerebral ischemia
- prostate cancer
- white matter
- stem cells
- small molecule
- poor prognosis
- oxidative stress
- gene expression
- drug delivery
- bone marrow
- binding protein
- endothelial cells
- multiple sclerosis
- cell cycle
- high grade
- pi k akt
- vascular endothelial growth factor
- brain injury
- amino acid
- long non coding rna