Meta-Analysis of Circulating Tumor Cell PD-L1 Expression and the Association with Clinical Outcomes in Non-Small Cell Lung Cancer.
Emmanuel AcheampongRebecca C AllsoppKaren PageMarc K WadsleyAaron B BeasleyR Charles CoombesJacqui A ShawElin Solomonovna GrayPublished in: Clinical chemistry (2024)
The average detection rate of PD-L1 + CTCs was comparable to the rate of PD-L1 expression in NSCLC tumors. There was a trend towards better PFS in ICI-treated NSCLC patients with PD-L1 + CTCs. Larger longitudinal studies on the association of PD-L1 + CTCs with clinical outcomes in NSCLC patients treated with ICIs are warranted.