Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet.
Seiryo OgataShingo ItoTakeshi MasudaSumio OhtsukiPublished in: Pharmaceutical research (2019)
Our results suggest that changes in the status of insulin resistance influence expression of BBB transporters, which in turn may alter the expression of cognitive function-related proteins.
Keyphrases
- high fat diet
- insulin resistance
- blood brain barrier
- high fat diet induced
- adipose tissue
- poor prognosis
- cerebral ischemia
- metabolic syndrome
- skeletal muscle
- polycystic ovary syndrome
- type diabetes
- binding protein
- white matter
- long non coding rna
- resting state
- fluorescent probe
- sensitive detection
- glycemic control
- brain injury
- drug induced
- quantum dots