Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages.
Ineta PopēnaArtūrs ĀbolsLīga SaulīteKārlis PleikoElīna ZandbergaKaspars JēkabsonsEdgars EndzeliņšAlicia LlorenteAija LinēUna RiekstiņaPublished in: Cell communication and signaling : CCS (2018)
Our results suggest that CRC cell line-derived EVs are internalized and reprogram the immunophenotype and secretory profile in monocytes and inactive macrophages inducing mixed M1 and M2 cytokine response. Although CRC EVs decreased HLA-DR expression in M1, M2 polarized macrophages, their effect on the secretory profile of M1 and M2 polarized macrophages was negligible.