HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression.
Suwellen Sardinha Dias de AzevedoMarcelo Ribeiro-AlvesFernanda Heloise CôrtesEdson DelatorreBrenda HoaglandLarissa M VillelaBeatriz GrinsztejnValdilea Gonçalvez VelosoMariza G MorgadoThiago Moreno L SouzaGonzalo BelloPublished in: Memorias do Instituto Oswaldo Cruz (2024)
These findings support the hypothesis that HICs activate innate antiviral mechanisms that may simultaneously downregulate the transcription of both exogenous (HIV-1) and endogenous (ERVK-6) retroviruses. Future studies with larger cohorts should be performed to confirm this hypothesis and to explore the role of p21 and MCPIP1 in regulating HERV-K expression in physiological and pathological conditions.