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Double-Stranded RNA to Mimic Viral Infection for Cancer Immunotherapy.

Ana Martinez-RiañoLaura MosteoPaula Molero-GlezIvan Marquez-RodasIgnacio Melero Bermejo
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
The presence of moieties denoting viral infection is crucial to mount powerful cytotoxic T-cell immune responses acting through innate receptors such as Toll-like receptor 3. For cancer immunotherapy, several safe analogues of viral double-stranded RNA are under clinical development following compelling evidence for efficacy in mouse models. See related article by van Eijck et al., p. 3447.
Keyphrases
  • toll like receptor
  • immune response
  • nucleic acid
  • nuclear factor
  • binding protein
  • mouse model
  • inflammatory response
  • dendritic cells
  • sars cov
  • molecular docking
  • molecular dynamics simulations