N-terminus of Etanercept is Proteolytically Processed by Dipeptidyl Peptidase-4.

Sho MasuiAtsushi YonezawaKotoko YokoyamaNoriko IwamotoTakashi ShimadaAkira OnishiHideo OnizawaTakayuki FujiiKosaku MurakamiKoichi MurataMasao TanakaShunsaku NakagawaDaiki HiraKotaro ItoharaSatoshi ImaiTakayuki NakagawaMakoto HayakariShuichi MatsudaAkio MorinobuTomohiro TeradaKazuo Matsubara

Published in: Pharmaceutical research (2022)

ETN undergoes N-terminal truncation in the body, and DPP-4 cleaves exogenous ETN via N-terminal proteolysis. The application of an MS-based assay will detect novel biotransformation of therapeutic proteins.

Keyphrases

mass spectrometry
rheumatoid arthritis
multiple sclerosis
high throughput
ms ms
ankylosing spondylitis
rheumatoid arthritis patients
juvenile idiopathic arthritis
disease activity
systemic lupus erythematosus
single cell