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Are inhaled mRNA vaccines safe and effective? A review of preclinical studies.

Evalyne M JansenHenderik W FrijlinkWouter L J HinrichsMitchel J R Ruigrok
Published in: Expert opinion on drug delivery (2022)
In our opinion, head-to-head comparison studies examining the safety and efficacy of intramuscular injected and pulmonary administered liquid mRNA vaccines should be performed first. When pulmonary delivered mRNA vaccines are shown to be effective and safe, inhalable dry powder formulations should be engineered. Finally, the tolerability of patients with respiratory diseases should be considered.
Keyphrases
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