Differential effects of mesalazine formulations on thiopurine metabolism through thiopurine S-methyltransferase inhibition.
Hiromu MorikuboTaku KobayashiRyo OzakiShinji OkabayashiSatoshi KuronumaOsamu TakeuchiTenyo ShibaHiroki KiyoharaMao MatsubayashiShintaro SagamiMasaru NakanoOsamu IkezakiTadakazu HisamatsuYoichi TanakaToshifumi HibiPublished in: Journal of gastroenterology and hepatology (2021)
Time-dependent mesalazine has higher plasma 5-ASA and N-Ac-5-ASA levels and greater TPMT inhibition than MMX. Therefore, switching from time-dependent mesalazine to MMX may lead to an increase of 6-MMP/6-TGN, which may reduce the clinical effectiveness of thiopurines, warranting close monitoring after switch.