Gender-dependent association between exhaled nitric oxide and the CC16 38AA genotype in young school children.
Sarah J D NauwelaertsNancy H C RoosensKoen De CremerAlfred BernardSigrid C J De KeersmaeckerPublished in: Immunity, inflammation and disease (2020)
Our study suggests that the CC16 38AA allele promotes airway inflammation as measured by FeNO through a gender-dependent association. Deficient levels of CC16 in the deep lung, measured noninvasively in urine, as a possible proxy for serum CC16, might underlie this promoting effect.