Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation.

Mei Hua GaoN Chin LaiDimosthenis GiamouridisYoung Chul KimTracy GuoH Kirk Hammond

Published in: PloS one (2017)

Mice with cardiac-directed AC6mut expression weathered the deleterious effects of continuous isoproterenol infusion better than control mice, indicating cardiac protection.

Keyphrases

poor prognosis
left ventricular
high fat diet induced
heart failure
low dose
binding protein
type diabetes
atrial fibrillation