Harnessing the therapeutic potential of phytochemicals in neuroblastoma.
Seyed Sajad AhmadiOmid BagherzadehMeysam SargaziFarnaz KalantarMohammad Amin Elahi NajafiMohammad Mahdi VahediAmir R AfshariAmir Hossein SahebkarPublished in: BioFactors (Oxford, England) (2024)
Neuroblastomas are the most common solid tumors outside of the brain that originate from immature neural crest cells, accounting for about 10% of all pediatric malignancies. The treatment for neuroblastomas involves a multimodal schedule, including surgery, radiation, chemotherapy, and immunotherapy. All these modalities are limited by side effects that might be severe, poor prognosis, and a high risk of recurrence. In the quest for additional therapeutic approaches, phytochemicals have attracted attention owing to their reported antitumor properties, safety, and multimechanistic mode of action. Several studies have used plant-derived bioactive compounds such as phenolics and flavonoids, suggesting modulation of biomolecules and signal transduction pathways involved in neuroblastoma. We reviewed the findings of recent preclinical and clinical studies demonstrating the effects of phytochemicals on neuroblastoma, shedding light on their molecular mechanism of action and potential therapeutic applications.
Keyphrases
- poor prognosis
- long non coding rna
- induced apoptosis
- minimally invasive
- cell cycle arrest
- coronary artery bypass
- working memory
- white matter
- early onset
- machine learning
- locally advanced
- pain management
- resting state
- big data
- endoplasmic reticulum stress
- squamous cell carcinoma
- blood brain barrier
- cell therapy
- case control
- radiation therapy
- multiple sclerosis
- artificial intelligence
- functional connectivity
- free survival
- combination therapy
- replacement therapy
- deep learning