Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.

H DingK HayashidaT SutoD D SukhtankarM KimuraV MendenhallMei-Chuan Ko

Published in: British journal of pharmacology (2015)

Taken together, these results demonstrated differential actions of ligands in the primate supraspinal region in regulating pain and itch. This study not only improves scientific understanding of the N/OFQ-NOP receptor system in pain processing but also supports the therapeutic potential of NOP-related ligands as analgesics.

Keyphrases

chronic pain
pain management
neuropathic pain
endothelial cells
postoperative pain
spinal cord injury
binding protein
pluripotent stem cells