Factors Associated With Complete Clinical Response and Remission in a Cohort of Romanian Children With Juvenile Dermatomyositis.
Andreea IoanOana M FarkasAlexis V CochinoPublished in: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (2024)
The median times to complete clinical response and time to remission for the entire cohort were 30.5 months (2.5 years) and 48.5 months (4.04 years), respectively. Nine patients (30%) had a severe disease course, while twenty-one patients (70%) had a mild/moderate course. The presence of calcinosis, time to corticosteroid discontinuation, history of treatment escalation in the first 18 months, and treatment with azathioprine or biologic DMARDs were strongly associated with a longer time to clinical remission (Pearson's > 0.5, p < 0.05). Seven patients (23%) achieved remission, and none of them relapsed during the subsequent median follow-up of 19 months.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- disease activity
- peritoneal dialysis
- rheumatoid arthritis
- acute lymphoblastic leukemia
- randomized controlled trial
- young adults
- clinical trial
- patient reported outcomes
- high intensity
- combination therapy
- replacement therapy
- hodgkin lymphoma