Macroline-Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana.
Joanne Soon-Yee YeapHazwani Mat SaadChun-Hoe TanKae-Shin SimSiew-Huah LimYun-Yee LowToh-Seok KamPublished in: Journal of natural products (2019)
A methanol extract of the stem bark of the Malayan Alstonia penangiana provided seven new bisindole alkaloids, comprising six macroline-sarpagine alkaloids (angustilongines E-K, 1-6) and one macroline-pleiocarpamine bisindole alkaloid (angustilongine L, 7). Analysis of the spectroscopic data (NMR and MS) of these compounds led to the proposed structures of these alkaloids. The macroline-sarpagine alkaloids (1-6) showed in vitro growth inhibitory activity against a panel of human cancer cell lines, inclusive of KB, vincristine-resistant KB, PC-3, LNCaP, MCF7, MDA-MB-231, HT-29, HCT 116, and A549 cells (IC50 values: 0.02-9.0 μM).
Keyphrases
- cell cycle arrest
- breast cancer cells
- endothelial cells
- high resolution
- induced apoptosis
- mass spectrometry
- multiple sclerosis
- oxidative stress
- papillary thyroid
- molecular docking
- electronic health record
- big data
- squamous cell carcinoma
- squamous cell
- induced pluripotent stem cells
- deep learning
- anti inflammatory
- molecular dynamics simulations
- pluripotent stem cells