A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae .
Mohamad YasminSteven H MarshallLiang ChenDaniel D RhoadsMichael R JacobsLaura J RojasFederico PerezAndrea M HujerKristine M HujerDavid Van DuinVance FowlerHenry F ChambersBarry N KreiswirthRobert A Bonomonull nullPublished in: Antimicrobial agents and chemotherapy (2024)
We characterized the molecular determinants of meropenem-vaborbactam (MV) non-susceptibility among non-metallo-β-lactamase-producing KPC- Klebsiella pneumoniae (KPC- KP ). Whole-genome sequencing was performed to identify mutations associated with MV non-susceptibility. Isolates with elevated MV MICs were found to have mutations encoding truncated or altered OmpK36 porins and increased bla KPC copy numbers. KPC- KP isolates with decreased susceptibility to MV were detected among a collection of isolates predating the availability of MV.