First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer.

Mark P S DunphyChristina PresslNagavarakishore PillarsettyMilan Grkovski Shanu ModiKomal JhaveriLarry Norton Bradley J BeattiePat B ZanzonicoDanuta ZatorskaTony TaldoneStefan O OchianaMohammad M UddinEva M BurnaziSerge K LyashchenkoClifford A HudisJacqueline BrombergHeiko M SchöderJosef J FoxHanwen ZhangGabriela ChiosisJason S Lewis Steven M Larson

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Our first-in-human results demonstrate the safety and feasibility of noninvasive in vivo detection of tumor epichaperomes using 124I-PU-H71 PET, supporting clinical development of PU-H71 and other epichaperome-targeted therapeutics.

Keyphrases

endothelial cells
computed tomography
induced pluripotent stem cells
cancer therapy
positron emission tomography
pluripotent stem cells
pet ct
clinical trial
study protocol
small molecule
pet imaging
quantum dots
open label